Silencing Nogo-A promotes functional recovery in demyelinating disease
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چکیده
منابع مشابه
Silencing Nogo-A promotes functional recovery in demyelinating disease.
OBJECTIVE To determine if suppressing Nogo-A, an axonal inhibitory protein, will promote functional recovery in a murine model of multiple sclerosis (MS). METHODS A small interfering RNA was developed to specifically suppress Nogo-A (siRNA-NogoA). The siRNA-NogoA silencing effect was evaluated in vitro and in vivo via immunohistochemistry. The siRNA was administered intravenously in 2 models ...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2009
ISSN: 0364-5134
DOI: 10.1002/ana.21935